There are not many large lakes in South America, the major ones are all salt or marshy basins, except Titicaca, located in the Andes at over 3,800 meters high.| Lake | Area (km²) |
Area (sq mi) |
Country |
| Lagoa dos Patos (1) | 9,850 | 3,803 | Brazil |
| Titicaca (2) | 8,372 | 3,232 | Bolivia, Perù |
| Ciénaga Grande de Santa Marta (3) | 4,280 | 1,653 | Colombia |
| Mar Chiquita (4) | 4,000 | 1,544 | Argentina |
| Laguna Merin | 3,750 | 1,448 | Brazil, Uruguay |
| Lago Buenos Aires (5) | 1,850 | 714 | Argentina, Chile |
| Lago Argentino | 1,466 | 566 | Argentina |
| Viedma | 1,088 | 420 | Argentina |
| San Martín (6) | 1,013 | 391 | Argentina, Chile |
| Lake Poopó (7) | 1,000 | 386 | Bolivia |
| Llanquihue | 860 | 332 | Chile |
| Colhué Huapi | 810 | 313 | Argentina |